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Nature Medicine 12, 585 - 591 (2006)
Published online: 23 April 2006; | doi:10.1038/nm1398

Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer

Brian D Brown, Mary Anna Venneri, Anna Zingale, Lucia Sergi Sergi & Luigi Naldini

 
Figure 1 thumbnailFigure 1.
Endogenous miRNAs effectively de-target gene expression from human hematopoietic cells.

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mir-142-3p mediates target mRNA degradation in hematopoietic cells in a robust and efficient manner.

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Figure 3 thumbnailFigure 3.
In vivo expression pattern of miRNA-regulated lentiviral vectors.

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mir-142-3p effectively segregates gene expression between hematopoietic and nonhematopoietic lineages throughout the organs of transgenic mice.

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Figure 5 thumbnailFigure 5.
miRNA-regulated lentiviral vector enables stable gene transfer in immunocompetent mice.

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