Nature Medicine
- 12, 515 - 517 (2006)
Published online: 23 April 2006; | doi:10.1038/nm1396
Coexpression of virulence and fosfomycin susceptibility in Listeria: molecular basis of an antimicrobial in vitro–in vivo paradoxMariela Scortti1, 2, 3, 4, Lizeth Lacharme-Lora1, 3, 4, Martin Wagner2, 4, 5, Isabel Chico-Calero2, Patrizia Losito1 & José A Vázquez-Boland1, 2, 31
Bacterial Molecular Pathogenesis Group, Faculty of Medical and Veterinary Sciences, University of Bristol, Langford BS40 5DU, UK. 2
Grupo de Patogénesis Molecular Bacteriana, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain. 3
Grupo de Patogénesis Molecular y Genómica Bacteriana, Facultad de Veterinaria, Universidad de León, 24071 León, Spain. 4
These authors contributed equally to this work. 5
Present address: University of Veterinary Medicine, 1210 Vienna, Austria.
Correspondence should be addressed to José A Vázquez-Boland v.boland@bristol.ac.uk Discrepancies between resistance in vitro and therapeutic efficacy in vivo are generally attributed to failure of laboratory susceptibility tests to reflect an antibiotic's pharmacokinetic or pharmacodynamic properties. We show here that this phenomenon can result from differential in vitro–in vivo expression of bacterial determinants of antibiotic susceptibility. We found that an in vivo–induced virulence factor, Hpt, also mediates uptake of fosfomycin in Listeria monocytogenes. These bacteria therefore seem resistant to fosfomycin in vitro, although they are in fact susceptible to the antibiotic during infection.
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