Nature Medicine 12, 446 - 451 (2006)
Published online: 26 March 2006; | doi:10.1038/nm1388
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cellsKeisuke Ito, Atsushi Hirao, Fumio Arai, Keiyo Takubo, Sahoko Matsuoka, Kana Miyamoto, Masako Ohmura, Kazuhito Naka, Kentaro Hosokawa, Yasuo Ikeda
& Toshio Suda Supplementary Fig. 1 (pdf 4M)
Effect of increased ROS on HSCs and progenitor cells. Supplementary Fig. 2 (pdf 2M)
Atm-/- HSCs are highly sensitive to ROS elevation in terms of p38 MAPK activation. Supplementary Fig. 3 (pdf 5M)
Treatment with a p38 MAPK inhibitor rescues defective HSC function in Atm-/- mice. Supplementary Fig. 4 (pdf 3M)
Elevation of ROS level and p16
Ink4a/p19
Arf expression in KSL cells during aging and serial transplantation. Supplementary Fig. 5 (pdf 3M)
In vitro treatment with a p38 MAPK inhibitor restores BSO-induced defective repopulating capacity of HSCs. Supplementary Table 1 (pdf 3M)
List of RT-PCR primers used in this study.
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