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Article
Nature Medicine 12, 425 - 432 (2006)
Published online: 2 April 2006; | doi:10.1038/nm1372

Induction of leptin resistance through direct interaction of C-reactive protein with leptin

Ke Chen, Fanghong Li, Ji Li, Hongbo Cai, Steven Strom, Alessandro Bisello, David E Kelley, Miriam Friedman-Einat, Gregory A Skibinski, Mark A McCrory, Alexander J Szalai & Allan Z Zhao

Supplementary Fig. 1 (pdf 72K)
Purification scheme of SLIPs and identification of human OBR.

Supplementary Fig. 2 (pdf 40K)
Purification of rat C-reactive protein.

Supplementary Fig. 3 (pdf 52K)
Quantification of leptin-induced STAT3 activation.

Supplementary Fig. 4 (pdf 40K)
Serum concentrations of human CRP and human leptin.

Supplementary Fig. 5 (pdf 36K)
Quantification of leptin-induced hypothalamic STAT3 activation.

Supplementary Table 1 (pdf 104K)
Nano-LC-MS/MS in-gel protein identification of h-SLIP-1.

Supplementary Table 2 (pdf 48K)
Identification of r-SLIP-1 with MALDI-TOF in-gel protein identification.

Supplementary Note (pdf 20K)


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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