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Nature Medicine 12, 383 - 384 (2006)
doi:10.1038/nm0406-383
Stem cell aging: what bleach can teach
- The authors are in the Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA. e-mail: finkelt@nih.gov
Abstract
Intracellular oxidants may contribute to overall lifespan, in part by affecting stem cells. The connection between oxidants and aging now gains strength in a study of hematopoietic stem cells, which respond to oxidants by activating a pathway leading to stem cell exhaustion (pages 446–451).
Late-night infomercials are filled with advertisements for dietary supplements that claim to be rich in natural antioxidants. Often, a well-tanned announcer encourages the viewer to purchase—in three easy installments—an all-natural way to live longer by fighting the body's harmful free radicals.
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RESEARCH
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cellsNature Medicine Letter (01 Apr 2006)
