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Nature Medicine 12, 425 - 432 (2006)
Published online: 2 April 2006; | doi:10.1038/nm1372

Induction of leptin resistance through direct interaction of C-reactive protein with leptin

Ke Chen, Fanghong Li, Ji Li, Hongbo Cai, Steven Strom, Alessandro Bisello, David E Kelley, Miriam Friedman-Einat, Gregory A Skibinski, Mark A McCrory, Alexander J Szalai & Allan Z Zhao

 
Figure 1 thumbnailFigure 1.
Purification of SLIPs and identification of SLIP-1.

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 Figure 2 thumbnailFigure 2.
Determination of CRP and leptin interaction.

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Figure 3 thumbnailFigure 3.
The effects of human or rat CRP on leptin signaling.

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 Figure 4 thumbnailFigure 4.
The effects of human CRP on the physiological functions of human leptin in ob/ob mice.

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Figure 5 thumbnailFigure 5.
Infusion or transgenic expression of human CRP attenuates the physiological functions of human leptin.

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 Figure 6 thumbnailFigure 6.
The effects of human leptin and IL-6 on expression of CRP.

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