Table 1 - Nature Medicine

Table 1

Nature Medicine 12, 479 (2006)
doi:10.1038/nm0406-479

ADDENDUM: Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

S S Gill, N K Patel, G R Hotton, K O'Sullivan, R McCarter, M Bunnage, D J Brooks, C N Svendsen & P Heywood

Table 1

	Baseline	3 months	6 months	12 months	18 months	24 months



P1	Madopar 250 mg TDS Ropinirole 2 mg TDS	Madopar 250 mg TDS Ropinirole 2 mg TDS	Madopar 250 mg TDS Ropinirole 2 mg TDS	Madopar 250 mg TDS Ropinirole 4 mg TDS	Madopar 250 mg TDS Ropinirole 4 mg TDS	Madopar 250 mg TDS Ropinirole 4 mg TDS
^{^*}	666.7	666.7	666.7	733.3	733.3	733.3
P2	Sinemet CR QDS Entacapone QDS	Sinemet Plus $times$ 5/day Sinemet CR nocte Tolcapone 100 mg TDS	Sinemet Plus $times$ 5/day Sinemet CR nocte Tolcapone 100 mg TDS	Sinemet Plus $times$ 5/day Sinemet CR nocte Tolcapone 100 mg TDS	Sinemet Plus $times$ 5/day Sinemet CR nocte Tolcapone 100 mg TDS	Sinemet Plus $times$ 5/day Sinemet CR nocte Tolcapone 100 mg TDS
^{^*}	615.4	653.8	653.8	653.8	653.8	653.8
P3	Madopar 125 mg $times$ 18–20/day Sinemet Half CR $times$ 1–2/day	Cabergoline 6 mg/day Sinemet Half CR $times$ 5–6/day	Cabergoline 6 mg/day Sinemet Half CR $times$ 5–6/day	Cabergoline 6 mg/day Sinemet Half CR $times$ 4–5/day	Cabergoline 6 mg/day Sinemet Half CR $times$ 4–5/day	Cabergoline 6 mg/day Sinemet Half CR $times$ 5–6/day
	2,153.8	1,061.5	1,061.5	984.6	984.6	1,061.5
P4	Sinemet Plus $times$ 6/day Lisuride 200 g QDS Selegiline 5 mg BD	Sinemet Plus $times$ 5/day Lisuride 200 g QDS Selegiline 5 mg BD	Sinemet Plus $times$ 2–3/day Lisuride 200 g QDS Selegiline 5 mg BD	Sinemet Plus $times$ 5–6/day Ropinirole 6 mg TDS	Sinemet Plus $times$ 6/day Lisuride 200 g $times$ 6	Sinemet Plus $times$ 6/day Amantadine 100 mg BD Pramipexole 0.7mg TDS
^{^*}	680	580	380	800	720	750
P5	Sinemet CR $times$ 3/day Sinemet Plus $times$ 1/day Cabergoline 2 mg/day Zelapar 1.25 mg OD	Cabergoline 4 mg/day Sinemet Plus $times$ 3–4/day Zelapar 1.25 mg OD	Cabergoline 2 mg/day Sinemet Plus $times$ 2.5–3/day Zelapar 1.25 mg OD	Cabergoline 2 mg/day Sinemet Plus $times$ 2.5/day Zelapar 1.25 md OD	Cabergoline 3 mg/day Sinemet Plus $times$ 2–2.5	Cabergoline 2.5 mg/day Sinemet Plus $times$ 1.75/day
^{^*}	761.5	800	500	450	500	425



^*Levodopa equivalents: 1 mg Pergolide = 1 mg lisuride = 10 mg Bromocriptine = 10 mg Apomorphine = 9 mg Ropinirole = 1 mg Cabergoline = 100 mg Levodopa + dopa decarboxylase inhibitor = 130 mg levodopa CR preparation.

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