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Protein twists and turns in Alzheimer disease

Nature Medicine volume 12, pages 392–393 (2006)Cite this article

An enzyme that modifies protein structure seems to help keep Alzheimer disease at bay. The enzyme affects two proteins thought to be key to disease pathology: amyloid precursor protein (APP) and the microtubule-binding protein tau.

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Figure 1: Pin-mediated prolyl isomerization in proteolytic processing of the amyloid precursor protein and cell cycle regulation.

Katie Ris

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Authors and Affiliations

  1. Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, 21224, Maryland, USA

    Stuart Maudsley & Mark P Mattson

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  1. Stuart Maudsley
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  2. Mark P Mattson
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Maudsley, S., Mattson, M. Protein twists and turns in Alzheimer disease. Nat Med 12, 392–393 (2006). https://doi.org/10.1038/nm0406-392

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