Nature Medicine 12, 317 - 323 (2006)
Published online: 12 February 2006; | doi:10.1038/nm1361
A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammationNathaniel M Weathington, Anneke H van Houwelingen, Brett D Noerager, Patricia L Jackson, Aletta D Kraneveld, F Shawn Galin, Gert Folkerts, Frans P Nijkamp
& J Edwin Blalock Supplementary Fig. 1 (pdf 796K)
PGP is chemotactic rather than chemokinetic, whereas the IL-8–derived peptide SGP chemotactic at similar concentrations; PGP causes PMN superoxide production, and competitively binds CXCR1 and CXCR2. Supplementary Fig. 2 (pdf 1M)
Identification and quantification of PGP (shown as N-a-PGP here) in the BAL fluids of LPS-treated mice. Supplementary Fig. 3 (pdf 728K)
PGP is cleared rapidly from airway fluid, is inhibited by monoclonal antibody 9A4, and causes alveolar enlargement and right ventricular hypertrophy in BALB/c mice.
|
