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Nature Medicine 12, 348-353 (1 March 2006) | doi:10.1038/nm1365;
Effective gene therapy with nonintegrating lentiviral vectors
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Abstract
Retroviral and lentiviral vector integration into host-cell chromosomes carries with it a finite chance of causing insertional mutagenesis. This risk has been highlighted by the induction of malignancy in mouse models, and development of lymphoproliferative disease in three individuals with severe combined immunodeficiency–X1 (refs.
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