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News and Views
Nature Medicine 12, 281 - 283 (2006)
doi:10.1038/nm0306-281
Plot against pot
Kerrie L Thomas1
- The author is at Cardiff University, School of Biosciences, Cardiff CF10 3US, UK. e-mail: thomaskl5@cf.ac.uk
Abstract
A small peptide administered into the brain of rats seems to abolish the rewarding effects of nicotine and THC. The peptide disrupts the interaction between a receptor for serotonin on dopamine-containing neurons and the tumor suppressor PTEN (pages 324–329).
Addicts exhibit persistent and compulsive behavioral sequences, akin to foraging, to obtain a drug of abuse. Early in the development of addiction, drug seeking is increased and reinforced by the highly valued rewarding effects of the drug.
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