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Nature Medicine 12, 280 - 281 (2006)
doi:10.1038/nm0306-280
The matrix degrades, neutrophils invade
Peter M Henson1 & R William Vandivier2
- Peter M. Henson is in the Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA. e-mail: hensonp@njc.org
- R. William Vandivier is at the COPD Center, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver Health Sciences Center, Denver, Colorado 80262, USA.
Abstract
A peptide fragment derived from extracellular matrix collagen attracts inflammatory cells by mimicking the activity of a chemokine—potentially contributing to lung injury (pages 317–323).
Infection or injury of tissues leads to an influx of neutrophils from the blood—an early step of acute inflammation that can be both protective and injurious. Within minutes of an insult, circulating neutrophils interact with vascular endothelium at the site of damage and begin their emigration from the blood vessels (Fig. 1
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