Nature Medicine
- 12, 304 - 306 (2006)
Published online: 26 February 2006; | doi:10.1038/nm1375
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathwaysKenneth Cardona1, 4, Gregory S Korbutt2, 4, Zvonimir Milas1, James Lyon2, Jose Cano1, Wanhong Jiang1, Hameeda Bello-Laborn1, Brad Hacquoil2, Elizabeth Strobert3, Shivaprakash Gangappa1, Collin J Weber1, Thomas C Pearson1, Ray V Rajotte2 & Christian P Larsen11
Emory Transplant Center, Department of Surgery, Emory University School of Medicine, 101 Woodruff Circle, Suite 5105, Atlanta, Georgia 30322, USA. 2
Surgical-Medical Research Institute, University of Alberta, 1074 Dentistry/Pharmacy Centre, Edmonton, Alberta, T6G 2N8, Canada. 3
Yerkes National Primate Research Center, Emory University School of Medicine, 954 Gatewood Road, Atlanta, Georgia 30322, USA. 4
These authors contributed equally to this work.
Correspondence should be addressed to Ray V Rajotte rrajotte@ualberta.ca or Christian P Larsen clarsen@emoryhealthcare.org We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.
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