Nature Medicine
- 12, 278 - 279 (2006)
doi:10.1038/nm0306-278
Stem cell mobilization by  2-agonistsJose A Cancelas & David A Williams
The authors are in the Division of Experimental Hematology, Cincinnati Children's Research Foundation, Cincinnati, Ohio 45229, USA. Jose A. Cancelas is also at the Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA. david.williams@cchmc.org
kanjiStem cells are mobilized from the bone marrow to the peripheral blood as a source of stem cells for transplantation in cancer and genetic diseases. Exactly how the mobilization-inducing drugs operate has not been clear—but the answer may lie partly with the stimulation of bone-forming cells by signals from the sympathetic nervous system.
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