Nature Medicine 12, 225 - 229 (2006)
Published online: 6 January 2006; | doi:10.1038/nm1362
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicityTakayuki Kawano, Josef Anrather, Ping Zhou, Laibaik Park, Gang Wang, Kelly A Frys, Alexander Kunz, Sunghee Cho, Marcello Orio
& Costantino Iadecola Supplementary Fig. 1 (pdf 521K)
SC51089 is neuroprotective without influencing physiological parameters. Supplementary Fig. 2 (pdf 738K)
SC51089 reduces the hippocampal damage produced byoxygen-glucose deprivation but not microglial activation. Supplementary Fig. 3 (pdf 9893K)
EP1 receptors are present in neurons. Supplementary Fig. 4 (pdf 6159K)
NMDA receptors, EP1 receptors, COX-2, and PGE2 synthase are present in neuronal cultures. Supplementary Fig. 5 (pdf 736K)
Effect of SC51089 on the [Ca++]i elevation elicited by glutamate and on Ca++ currents. Supplementary Methods (pdf 73K)
Methods for assessment of neurological deficits.
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