Nature Medicine 12, 235 - 239 (2006)
Published online: 5 February 2006; | doi:10.1038/nm1351
Angiopoietin-2 sensitizes endothelial cells to TNF- and has a crucial role in the induction of inflammationUlrike Fiedler, Yvonne Reiss, Marion Scharpfenecker, Verena Grunow, Stefanie Koidl, Gavin Thurston, Nicholas W Gale, Martin Witzenrath, Simone Rosseau, Norbert Suttorp, Astrid Sobke, Matthias Herrmann, Klaus T Preissner, Peter Vajkoczy
& Hellmut G Augustin Supplementary Fig. 1 (pdf 20K) Breeding statistics of Ang-2-deficient mice bred in the C57Bl6 background and in the 129/J background. Supplementary Fig. 2 (pdf 68K) Ang-2 expression and storage in human tissues. Supplementary Fig. 3 (pdf 32K) Analysis of cells recruited into the lung of wild type and Ang2-deficient mice after Streptococcus pneumoniae infection. Supplementary Fig. 4 (pdf 48K) Tie2 expression in different cell populations. Supplementary Methods (pdf 32K) Supplementary Video 1 (mpg 2M) Baseline leukocyte rolling in wild-type mice. Supplementary Video 2 (mov 1M) Baseline leukocyte rolling in Angptl2-/- mice. Supplementary Video 3 (mov 1M) Leukocyte adhesion in wild-type mice 1 h after TNF- treatment. Supplementary Video 4 (mov 1M) Leukocyte rolling in Angptl2-/- mice 1 h after TNF-a treatment.
|