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Letter
Nature Medicine 12, 235 - 239 (2006)
Published online: 5 February 2006; | doi:10.1038/nm1351

Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation

Ulrike Fiedler, Yvonne Reiss, Marion Scharpfenecker, Verena Grunow, Stefanie Koidl, Gavin Thurston, Nicholas W Gale, Martin Witzenrath, Simone Rosseau, Norbert Suttorp, Astrid Sobke, Matthias Herrmann, Klaus T Preissner, Peter Vajkoczy & Hellmut G Augustin

Supplementary Fig. 1 (pdf 20K)
Breeding statistics of Ang-2-deficient mice bred in the C57Bl6 background and in the 129/J background.

Supplementary Fig. 2 (pdf 68K)
Ang-2 expression and storage in human tissues.

Supplementary Fig. 3 (pdf 32K)
Analysis of cells recruited into the lung of wild type and Ang2-deficient mice after Streptococcus pneumoniae infection.

Supplementary Fig. 4 (pdf 48K)
Tie2 expression in different cell populations.

Supplementary Methods (pdf 32K)

Supplementary Video 1 (mpg 2M)
Baseline leukocyte rolling in wild-type mice.

Supplementary Video 2 (mov 1M)
Baseline leukocyte rolling in Angptl2-/- mice.

Supplementary Video 3 (mov 1M)
Leukocyte adhesion in wild-type mice 1 h after TNF-alpha treatment.

Supplementary Video 4 (mov 1M)
Leukocyte rolling in Angptl2-/- mice 1 h after TNF-a treatment.


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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