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Letter

Nature Medicine 12, 230–234 (1 February 2006) | doi:10.1038/nm1340

Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants

Dontscho Kerjaschki , Nicole Huttary , Ingrid Raab , Heinz Regele , Katalin Bojarski-Nagy , Gregor Bartel , Stefan M Kr|[ouml]|ber , Hildegard Greinix , Agathe Rosenmaier , Franz Karlhofer , Nikolaus Wick & Peter R Mazal

De novo lymphangiogenesis influences the course of different human diseases as diverse as chronic renal transplant rejection and tumor metastasis. The cellular mechanisms of lymphangiogenesis in human diseases are currently unknown, and could involve division of local preexisting endothelial cells or incorporation of circulating progenitors.