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Nature Medicine 12, 168 - 169 (2006)
doi:10.1038/nm0206-168
Oxygen deprivation provokes melanoma
Amy E Adams1, Yakov Chudnovsky1 & Paul A Khavari1,2
- The authors are in the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
- Paul A. Khavari is also in the Veterans Affairs Palo Alto Healthcare System, Palo Alto, California 94304, USA. e-mail: khavari@cmgm.stanford.edu
Abstract
Melanoma may be promoted by low oxygen conditions in the skin, which turn on the oxygen-response regulator HIF-1. HIF-1 seems to act in concert with well-established oncoproteins to promote tumorigenesis—a process that responds to the drug rapamycin.
Cancer does not arise in a vacuum. Individual tumor types originate in tissue microenvironments with distinctive features, such as specific cell-matrix contacts and variations in local blood supply.
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