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Nature Medicine 12, 1352 - 1353 (2006)
doi:10.1038/nm1206-1352
Alzheimer protease hitches a ride
Michael S Wolfe1
- The author is at the Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, H.I.M. 754, Boston, Massachusetts 02115, USA. e-mail: mwolfe@rics.bwh.harvard.edu
Abstract
Activation of certain G protein–coupled receptors stimulates production of the neurotoxic amyloid-
peptide through internalization of a membrane-embedded protease (pages 1390–1396).
Hitchhiking is generally ill-advised, but who would have suspected that it might have implications for dementia? The pathogenesis of Alzheimer disease is intimately linked to the production and self-assembly of the aggregation-prone, 4-kDa amyloid- peptide1, 2.
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