Nature Medicine
- 12, 1359 - 1361 (2006)
doi:10.1038/nm1206-1359
Fat fuels insulin resistance through Toll-like receptorsMatthias Tschöp1 & George Thomas21
Department of Psychiatry, Obesity Research Center, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio, USA. tschoem@ucmail.uc.edu
2
Department of Genome Sciences, Obesity Research Center, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio, USA. kanjiDietary lipids seem to activate a Toll-like receptor, which is better known for its defense against infectious pathogens. The findings suggest that the resulting inflammatory response may link obesity with type 2 diabetes.
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