Nature Medicine
- 12, 1358 - 1359 (2006)
doi:10.1038/nm1206-1358
Skin controls immune regulatorsTomoyuki Yamaguchi1 & Shimon Sakaguchi1, 21
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. tyamaguc@frontier.kyoto-u.ac.jp
2
Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Kawaguchi 332-0012, Japan. kanjiAn explanation has come to light for the long-observed phenomenon that ultraviolet light suppresses the immune response in the skin. Light and other stimuli prompt the proliferation of regulatory T cells through the upregulation of receptor activator of NF- B ligand (RANKL) on skin cells (pages 1372–1379).
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