Nature Medicine
- 12, 1354 - 1356 (2006)
doi:10.1038/nm1206-1354
Cancer gets the Chk'ered flagLiu Cao & Toren Finkel
The authors are in the Cardiology Branch of the National Heart, Lung and Blood Institute, US National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA. finkelt@nih.gov
kanjiCertain oncogenes seem to be able to trigger cellular senescence and growth arrest, thereby holding cancer at bay. Two new studies suggest that oncogenes trigger senescence through activation of a pathway initially described as sensing DNA damage.
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