Nature Medicine
- 12, 1259 - 1268 (2006)
Published online: 22 October 2006; | doi:10.1038/nm1495
Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytesNeeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal & Steven A Goldman Supplementary Fig. 1 (pdf 132K)
Dopaminergic neurons may be induced at high efficiency from H1 HES cells. Supplementary Fig. 2 (pdf 680K)
Neuronal phenotypes in cultures of differentiated H9 and H1 cells consists of minor populations of GABAergic and serotonergic cells. Supplementary Fig. 3 (pdf 116K)
HES-derived dopaminergic neurons are of A9 phenotype and functionally active. Supplementary Fig. 4 (pdf 344K)
Animals transplanted with H1-derived cells show functional improvement as well as histological integration and differentiation of xenografted cells. Supplementary Fig. 5 (pdf 208K)
Transplanted naive HES cells rapidly generate teratomas. Supplementary Methods (pdf 88K)
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