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Feeding signals and drugs meet in the midbrain

Nature Medicine volume 12, pages 1244–1246 (2006)Cite this article

Three studies show that overeating may share neurobiological mechanisms with the addictive properties of drugs of abuse.

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Figure 1: Major neural pathways impacted by leptin and ghrelin that mediate reward and energy balance.

References

  1. Hommel, J.D. et al. Neuron 51, 801–810 (2006).

    Article  CAS  Google Scholar 

  2. Fulton, S. et al. Neuron 51, 811–822 (2006).

    Article  CAS  Google Scholar 

  3. Abizaid, A. et al. J. Clin. Invest. published online 20 October 2006 (doi: 10.1172/JCI29867).

  4. Volkow, N.D. & Wise, R.A. Nat. Neurosci. 8, 555–560 (2005).

    Article  CAS  Google Scholar 

  5. Robinson, T.E. & Berridge, K.C. Brain Res. Brain Res. Rev. 18, 247–291 (1993).

    Article  CAS  Google Scholar 

  6. Benoit, S.C., Clegg, D.J., Seeley, R.J. & Woods, S.C. Recent Prog. Horm. Res. 59, 267–285 (2004).

    Article  CAS  Google Scholar 

  7. Zigman, J.M. & Elmquist, J.K. Endocrinology 144, 3749–3756 (2003).

    Article  CAS  Google Scholar 

  8. Saper, C.B., Chou, T.C. & Elmquist, J.K. Neuron 36, 199–211 (2002).

    Article  CAS  Google Scholar 

  9. Kelley, A.E. Neurosci. Biobehav. Rev. 27, 765–776 (2004).

    Article  Google Scholar 

  10. Szczypka, M.S., Rainey, M.A. & Palmiter, R.D. Nat. Genet. 25, 102–104 (2000).

    Article  CAS  Google Scholar 

  11. Fulton, S., Richard, D., Woodside, B. & Shizgal, P. Behav. Brain Res. 155, 319–329 (2004).

    Article  CAS  Google Scholar 

  12. Figlewicz, D.P. et al. Behav. Neurosci. 118, 479–487 (2004).

    Article  CAS  Google Scholar 

  13. Hao, J., Cabeza de Vaca, S. & Carr, K.D. Physiol. Behav. 83, 377–381 (2004).

    Article  CAS  Google Scholar 

  14. Vezina, P. Neurosci. Biobehav. Rev. 27, 827–839 (2004).

    Article  CAS  Google Scholar 

  15. Naleid, A.M., Grace, M.K., Cummings, D.E. & Levine, A.S. Peptides 26, 2274–2279 (2005).

    Article  CAS  Google Scholar 

  16. Lu, X.Y., Kim, C.S., Frazer, A. & Zhang, W. Proc. Natl. Acad. Sci. USA 103, 1593–1598 (2006).

    Article  CAS  Google Scholar 

Download references

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  1. Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, 4650 Sunset Boulevard, Los Angeles, 90027, California, USA

    Richard Simerly

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  1. Richard Simerly
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Simerly, R. Feeding signals and drugs meet in the midbrain. Nat Med 12, 1244–1246 (2006). https://doi.org/10.1038/nm1106-1244

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