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News and Views
Nature Medicine 12, 1246 - 1248 (2006)
doi:10.1038/nm1106-1246
Virus scores a perfect 10
Paul Klenerman1 & Burkhard Ludewig2
- Paul Klenerman is in the Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, UK. e-mail: paul.klenerman@ndm.ox.ac.uk
- Burkhard Ludewig is in the Research Department, Kantonal Hospital St. Gallen, CH-9007 St. Gallen, Switzerland. e-mail: Burkhard.Ludewig@kssg.ch
Abstract
Blockade of a single cytokine—interleukin-10—can re-energize T cells 'exhausted' by persistent virus infection. The findings have implications for controlling HIV and other persistent viruses (pages 1301–1309).
Forming a long-term relationship with a virus involves a tricky decision for the host. A strong immune response might lead to better control of the pathogen, but, at the same time, such responses can potentially cause substantial tissue damage, so sometimes a little tolerance is required.
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