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Nature Medicine 12, 1243 - 1244 (2006)
doi:10.1038/nm1106-1243
Feeling pain? Who's your daddy...
Gavril W Pasternak1 & Charles E Inturrisi2
- Gavril W. Pasternak is in the Department of Neurology and the Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA. e-mail: pasterng@mskcc.org
- Charles E. Inturrisi is in the Departments of Pharmacology and Neurology & Neuroscience, Weill College of Medicine of Cornell University, 1300 York Avenue, New York, New York 10021, USA.
Abstract
A new modulator of pain comes to light in studies of rats and people (pages 1269–1277).
The most feared consequence of pain from disease or trauma is the possibility that it will become chronic, persisting long beyond the normal recovery time. However, not every herniated disc leads to chronic back pain and not every patient with herpes zoster infection develops postherpetic neuralgia.
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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistenceNature Medicine Article (01 Nov 2006)
