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Correspondence

Nature Medicine 12, 1231 (2006)
doi:10.1038/nm1106-1231a

Melanoma pathogenesis and Nodal: a partial picture?

David S Salomon1

  1. Chief, Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. e-mail: salomond@mail.nih.gov

After reading the article by Topczewska et al.1 implicating the role of the embryonic morphogen Nodal in melanoma pathogenesis, which I found to be extremely interesting, I was struck by the lack of scientific and historical perspective displayed by the authors. In particular, there is no mention or citation within their article of the possible expression of Cripto-1 in melanomas and its potential interactions with Nodal.

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