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Volume 12 Issue 11, November 2006

Neurons positive for III-tubulin expressing tyrosine hydroxylase after serial induction and differentiation in astrocyte coculture. In this issue, Goldman and colleagues show that these neurons can induce recovery in a model of Parkinson disease, but highlight their potential to become tumorigenic. Photo courtesy of Steven Goldman.

Volume 12 Issue 11

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News & Views

  • The goal of replacing dying cells in Parkinson disease with stem cells is now brought a step closer to the clinic. A new protocol eases symptoms in a rat model of the disease, but also raises the concern that poorly differentiated cells have the potential to become tumorigenic (pages 1259–1268).

    • Christian T Carson
    • Stefan Aigner
    • Fred H Gage
    News & Views

  • A molecular basis for the metabolic abnormalities observed in Huntington disease is emerging. Transcription of a key mitochondrial regulator, PGC-1α, is dysregulated by mutant huntingtin, leading to oxidative stress and excitotoxicity. The findings dovetail with previous work implicating aberrant transcription in Huntington disease, and have implications for related conditions such as Parkinson disease.

    • Christopher A Ross
    • Leslie Michels Thompson
    News & Views

  • New findings in humans examine how mitochondrial function declines during Alzheimer disease.

    • Michael T Lin
    • M Flint Beal
    News & Views

  • A new modulator of pain comes to light in studies of rats and people (pages 1269–1277).

    • Gavril W Pasternak
    • Charles E Inturrisi
    News & Views

  • Blockade of a single cytokine—interleukin-10—can re-energize T cells 'exhausted' by persistent virus infection. The findings have implications for controlling HIV and other persistent viruses (pages 1301–1309).

    • Paul Klenerman
    • Burkhard Ludewig
    News & Views
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