Nature Medicine
- 12, 1253 - 1255 (2006)
Published online: 29 October 2006; | doi:10.1038/nm1501
Identification of a hormonal basis for gallbladder fillingMihwa Choi1, Antonio Moschetta2, Angie L Bookout3, Li Peng1, Michihisa Umetani3, Sam R Holmstrom3, Kelly Suino-Powell4, H Eric Xu4, James A Richardson5, Robert D Gerard1, 6, David J Mangelsdorf3, 7 & Steven A Kliewer1, 31
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA. 2
Consorzio Mario Negri Sud, Via Nazionale 8A, Santa Maria Imbaro Chieti, Chieti 66030, and Clinica Medica Murri, University of Bari, Policlinico, Bari 70124, Italy. 3
Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390, USA. 4
Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, Michigan 49503, USA. 5
Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA. 6
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA. 7
The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Correspondence should be addressed to Steven A Kliewer steven.kliewer@utsouthwestern.edu The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility.
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