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Letter
Nature Medicine - 12, 1181 - 1184 (2006)
Published online: 1 October 2006; | doi:10.1038/nm1487

Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications

Ingo Roeder, Matthias Horn, Ingmar Glauche, Andreas Hochhaus, Martin C Mueller & Markus Loeffler

Supplementary Fig. 1 (pdf 136K)
Simulation of CML genesis.

Supplementary Fig. 2 (pdf 232K)
Transition characteristics.

Supplementary Fig. 3 (pdf 588K)
Individual subject data.

Supplementary Fig. 4 (pdf 192K)
Model prediction for combination of imatinib with cytotoxic treatment.

Supplementary Fig. 5 (pdf 196K)
Computer simulation of prolonged imatinib administration.

Supplementary Table 1 (pdf 60K)
Model parameters for normal and leukemic cells.

Supplementary Table 2 (pdf 52K)
Model parameters for treatment simulation.

Supplementary Note (pdf 208K)


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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