Nature Medicine
- 12, 1121 - 1123 (2006)
doi:10.1038/nm1006-1121
Alzheimer disease: presenilin springs a leakSam Gandy1, Mark K Doeven2 & Bert Poolman31
Sam Gandy is at the Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. samgandy@earthlink.net
2
Mark K. Doeven is at the Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA, and the Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, The Netherlands. 3
Bert Poolman is at the Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, The Netherlands. kanjiPresenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid- peptides. A new function for presenilins now comes to light—controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the 'amyloid hypothesis' of Alzheimer disease?
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