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Nature Medicine 12, 43–44 (1 January 2006) | doi:10.1038/nm0106-43

The humoral side of insulin resistance

Mitchell A Lazar

There is not much amusing about type 2 diabetes and cardiovascular disease, conditions that threaten individual lifespan in the industrialized world. Insulin resistance, most commonly in the context of obesity, is the major risk factor for these devastating diseases.