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Nature Medicine 12, 8 - 9 (2006)
Published online: 29 December 2005 | doi:10.1038/nm0106-8

News Feature: Hormone in the hot seat

Apoorva Mandavilli1

  1. Apoorva Mandavilli is Nature Medicine's senior news editor.


Three years after scientists declared estrogen harmful to the heart, some say the hormone was unfairly maligned. Apoorva Mandavilli finds out why it's time to reopen the debate.


For millions of women, the news was downright disheartening. After decades of touting estrogen as a fountain of youth, scientists announced in July 2002 that taking a combination of the hormones estrogen and progesterone makes menopausal women slightly more likely to have breast cancer, heart attacks and strokes1.

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