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Special Feature: News and Views
Nature Medicine 12, 43 - 44 (2006)
doi:10.1038/nm0106-43
The humoral side of insulin resistance
Mitchell A Lazar1
Abstract
Primary alterations in insulin signaling pathways are not the only way to reduce the body's sensitivity to insulin. By promoting the release of cytokines, liver inflammation can also lead to insulin resistance.
There is not much amusing about type 2 diabetes and cardiovascular disease, conditions that threaten individual lifespan in the industrialized world. Insulin resistance, most commonly in the context of obesity, is the major risk factor for these devastating diseases1.
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