Nature Medicine
11, 936 - 943 (2005)
Published online: 28 August 2005; | doi:10.1038/nm1284
Blockade of PI3K suppresses joint inflammation and damage in mouse models of rheumatoid arthritisMontserrat Camps, Thomas Rückle, Hong Ji, Vittoria Ardissone, Felix Rintelen, Jeffrey Shaw, Chiara Ferrandi, Christian Chabert, Corine Gillieron, Bernard Françon, Thierry Martin, Denise Gretener, Dominique Perrin, Didier Leroy, Pierre-Alain Vitte, Emilio Hirsch, Matthias P Wymann, Rocco Cirillo, Matthias K Schwarz
& Christian Rommel Supplementary Fig. 1 (pdf 44K)
Determination of the kinetic parameters of the four different PI3K isoforms. Supplementary Fig. 2 (pdf 24K)
Kinase selectivity profile of LY294002, AS-604850, AS-605240 and AS-605091. Supplementary Fig. 3 (pdf 24K)
Determination of in vitro and in vivo pharmacological parameters of AS-605240. Supplementary Table 1 (pdf 16K)
Enzymatic parameters for Class I PI3K isoforms, obtained from the experiments shown in Supplementary Fig. 1. Supplementary Table 2 (pdf 20K)
Summary of the crystallographic information obtained from PI3K crystals soaked with AS-604850 and AS-605240. Supplementary Table 3 (pdf 16K)
Selectivity profile of PI3K inhibitors for Class I PI3K isoforms. Supplementary Methods (pdf 32K)
|
