Access
To read this story in full you will need to login or make a payment (see right).
Brief Communication
Nature Medicine 11, 933 - 935 (2005)
Published online: 28 August 2005 | doi:10.1038/nm1291
PI3K
inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
Domingo F Barber1, Almira Bartolomé1, Carmen Hernandez1, Juana M Flores2, Clara Redondo3, Cristina Fernandez-Arias1, Montserrat Camps4, Thomas Rückle4, Matthias K Schwarz4, Santiago Rodríguez1, Carlos Martinez-A1, Dimitrios Balomenos1, Christian Rommel4 & Ana C Carrera1
Abstract
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease generated by deregulation of T cell–mediated B-cell activation, which results in glomerulonephritis and renal failure. Disease is treated with immunosuppressants and cytostatic agents that have numerous side effects. Here we examine the use of inhibitors of phosphoinositide 3-kinase (PI3K) 
, a lipid kinase that regulates inflammation, in the MRL-lpr mouse model of SLE. Treatment reduced glomerulonephritis and prolonged lifespan, suggesting that P13K may be a useful target in the treatment of chronic inflammation.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Modulating autoimmunity: pick your PI3 kinaseNature Medicine News and Views (01 Sep 2005)
Positive selection for autoimmunityNature Medicine News and Views (01 Mar 2000)
RESEARCH
Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic?ischemic ratsJournal of Cerebral Blood Flow & Metabolism Original Article
Proline scanning mutagenesis of a molten globule reveals non-cooperative formation of a protein's overall topologyNature Structural Biology Article (01 Aug 1996)
See all 49 matches for Research