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Nature Medicine 11, 924 - 925 (2005)
doi:10.1038/nm0905-924
Modulating autoimmunity: pick your PI3 kinase
Pamela S Ohashi1 & James R Woodgett2
- Pamela S. Ohashi is at the Ontario Cancer Institute, Toronto, Ontario M5G 2M9 and the Campbell Family Institute for Breast Cancer Research, Toronto, Ontario M5C 2M1, Canada. e-mail: pohashi@uhnres.utoronto.ca
- James R. Woodgett is at the Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada.
Abstract
Small molecules that specifically inhibit PI3K
block disease in mouse models of arthritis and lupus (pages 936–943).
Drugs that target enzymes with multiple isoforms run the risk of affecting too many cellular processes, because many isoforms perform redundant functions. Gene knockout mice of these molecules, however, often reveal selective roles, raising the possibility of precise modulation through use of highly specific, isoform-selective drugs.
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