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Nature Medicine  11, 936 - 943 (2005)
Published online: 28 August 2005; | doi:10.1038/nm1284

Blockade of PI3Kbig gamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Montserrat Camps, Thomas Rückle, Hong Ji, Vittoria Ardissone, Felix Rintelen, Jeffrey Shaw, Chiara Ferrandi, Christian Chabert, Corine Gillieron, Bernard Françon, Thierry Martin, Denise Gretener, Dominique Perrin, Didier Leroy, Pierre-Alain Vitte, Emilio Hirsch, Matthias P Wymann, Rocco Cirillo, Matthias K Schwarz & Christian Rommel

 
Figure 1 thumbnailFigure 1.
Inhibitory profile and binding mode of PI3K inhibitors.

Full FigureFull Figure and legend (98K)		 Figure 2 thumbnailFigure 2.
PI3Kgamma inhibitors block chemoattractant-mediated PKB phosphorylation in macrophages and primary monocytes.

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Figure 3 thumbnailFigure 3.
Effects of PI3Kgamma inhibitors on in vitro and in vivo chemotaxis.

Full FigureFull Figure and legend (42K)		 Figure 4 thumbnailFigure 4.
Elimination of PI3Kgamma function largely protects against alphaCII-IA.

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Figure 5 thumbnailFigure 5.
Effects of AS-605240 in mouse CIA.

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