Chris A. Benedict and Carl F. Ware are in the Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA. benedict@liai.org or cware@liai.org
Molecules that recognize pathogens and activate the immune response are being discovered at a rapid rate. RIG-I, a new protein in this category, recognizes viral RNA. Recent studies show that RIG-I operates independently of Toll-like receptors and that it is targeted for inactivation by the hepatitis C virus.
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