Nature Medicine
11, 927 - 928 (2005)
doi:10.1038/nm0905-927
A plague upon the phagocytesFrank R DeLeo
& B Joseph Hinnebusch
Frank R. DeLeo is in the Laboratory of Human Bacterial Pathogenesis and B. Joseph Hinnebusch is in the Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA. fdeleo@niaid.nih.gov or jhinnebusch@niaid.nih.gov
Plague bacteria are renowned for causing some of the most devastating epidemics in human history. We are now closer to understanding why: the pathogen selectively disarms key cells of the innate immune system, weakening the front-line defenses of the body.
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