The authors are at the Cold Spring Harbor Laboratory and Scott W. Lowe is also at the Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA. lowe@cshl.edu
Normal cells can respond to expression of activated oncogenes by initiating cellular senescence, a permanent state of proliferative arrest. But whether this process reflects a relevant anticancer mechanism has been debated. Several studies now show that oncogene-induced senescence can occur in vivo and provides a bona fide barrier to tumorigenesis.
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