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News and Views
Nature Medicine 11, 722 - 723 (2005)
doi:10.1038/nm0705-722
There is a Corrigendum (August 2005) associated with this News and Views.
Old fat, make way for new fat
Geoff Gibbons1
- The author is in the Metabolic Research Laboratory at the Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK. e-mail: geoff.gibbons@mri.ox.ac.uk
Abstract
PPAR
reduces fat accumulation and enhances insulin sensitivity, but exactly how it operates has been unclear. Work on mice suggests that newly synthesized fat—but not preexisting fat—activates this transcription factor.
Excess fat in the liver occurs in about 25% of adults in many Western countries. Fatty liver, also known as lipotoxic disease1, is associated with obesity, type 2 diabetes2 and its precursor, insulin resistance.
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