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Genome instability in progeria: when repair gets old

Nature Medicine volume 11, pages 718–719 (2005)Cite this article

Genome instability and DNA repair defects have been discovered in the premature aging disease Hutchinson-Gilford progeria syndrome. These findings provide the first hint of a molecular mechanism for a group of human conditions caused by defects in the nuclear structural protein lamin A (pages 780–785).

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Figure 1: Lamin A–processing defects in laminopathies.

References

  1. Burke, B. & Stewart, C.L. Nat. Rev. Mol. Cell Biol. 3, 575–585 (2002).

    Article  CAS  Google Scholar 

  2. Pollex, R.L. & Hegele, R.A. Clin. Genet. 66, 375–381 (2004).

    Article  CAS  Google Scholar 

  3. Liu, B. et al. Nat. Med. 11, 780–785 (2005).

    Article  CAS  Google Scholar 

  4. De Sandre-Giovannoli, A. et al. Am. J. Hum. Genet. 70, 726–736 (2002).

    Article  CAS  Google Scholar 

  5. Eriksson, M. et al. Nature 423, 293–298 (2003).

    Article  CAS  Google Scholar 

  6. Scaffidi, P. & Misteli, T. Nat. Med. 11, 440–445 (2005).

    Article  CAS  Google Scholar 

  7. Goldman, R.D. et al. Proc. Natl. Acad. Sci. USA 101, 8963–8968 (2004).

    Article  CAS  Google Scholar 

  8. Lombard, D.B. et al. Cell 120, 497–512 (2005).

    Article  CAS  Google Scholar 

  9. Goldman, R.D., Gruenbaum, Y., Moir, R.D., Shumaker, D.K. & Spann, T.P. Genes Dev. 16, 533–547 (2002).

    Article  CAS  Google Scholar 

  10. Agarwal, A.K., Fryns, J.P., Auchus, R.J. & Garg, A. Hum. Mol. Genet. 12, 1995–2001 (2003).

    Article  CAS  Google Scholar 

  11. Navarro, C.L. et al. Hum. Mol. Genet. 13, 2493–2503 (2004).

    Article  CAS  Google Scholar 

Download references

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  1. National Cancer Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Tom Misteli & Paola Scaffidi

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  1. Tom Misteli
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Misteli, T., Scaffidi, P. Genome instability in progeria: when repair gets old. Nat Med 11, 718–719 (2005). https://doi.org/10.1038/nm0705-718

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