Genome instability in progeria: when repair gets old
Tom Misteli
& Paola Scaffidi
The authors are at the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. mistelit@mail.nih.gov
Genome instability and DNA repair defects have been discovered in the premature aging disease Hutchinson-Gilford progeria syndrome. These findings provide the first hint of a molecular mechanism for a group of human conditions caused by defects in the nuclear structural protein lamin A (pages 780−785).
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