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Nature Medicine  11, 599 - 600 (2005)
doi:10.1038/nm0605-599

A low-carb diet for a high-octane pathogen

H I Boshoff & C E Barry III

The authors are in the Tuberculosis Research Section, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland 20852, USA. cbarry@niaid.nih.gov

Mycobacterium tuberculosis adapts to the low-glucose conditions in its host by using lipids as a fuel source. This adaptation reveals a weak flank that might be exploited in drug development, as shown in work on mice and human cells (pages 638−644).

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ISSN: 1078-8956
EISSN: 1546-170X
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