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News and Views
Nature Medicine 11, 478 - 479 (2005)
doi:10.1038/nm0505-478
Muscle disease: a giant feels the strain
Larissa Tskhovrebova1 & John Trinick1
- The authors are at the School of Biomedical Sciences, Leeds University, Leeds LS2 9JT, UK. e-mail: jtrinick@bmbaxp.leeds.ac.uk, e-mail: l.tskhovrebova@leeds.ac.uk
Abstract
Titin is a massive protein that provides mechanical and structural support in striated muscles. Titin is now implicated in a new signaling pathway that seems to control gene expression. Loss of this pathway as a result of a mutation in titin leads to hereditary muscle disease.
Titin is the largest protein known, weighing in at 3.5 megaDaltons.
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