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Nature Medicine  11, 522 - 530 (2005)
Published online: 24 April 2005; | doi:10.1038/nm1240

Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus

Theodore Oliphant, Michael Engle, Grant E Nybakken, Chris Doane, Syd Johnson, Ling Huang, Sergey Gorlatov, Erin Mehlhop, Anantha Marri, Kyung Min Chung, Gregory D Ebel, Laura D Kramer, Daved H Fremont & Michael S Diamond
 
Figure 1 thumbnailFigure 1.
Mapping of monoclonal antibodies to DIII with yeast.

Full FigureFull Figure and legend (90K)		 Figure 2 thumbnailFigure 2.
Fine epitope mapping of DIII neutralizing and non-neutralizing monoclonal antibodies.

Full FigureFull Figure and legend (130K)		 
 
Figure 3 thumbnailFigure 3.
Therapeutic effect of DIII-neutralizing monoclonal antibodies.

Full FigureFull Figure and legend (84K)		 Figure 4 thumbnailFigure 4.
Construction and efficacy of humanized E16.

Full FigureFull Figure and legend (96K)		 
 
Figure 5 thumbnailFigure 5.
Efficacy of mouse E16 in complement and Fcgr1- and Fcgr3-deficient mice.

Full FigureFull Figure and legend (35K)		 Table 1 thumbnailTable 1.
Binding of monoclonal antibodies to domain III variants on the surface of yeast

Full TableFull Table		 
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