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Letter
Nature Medicine 11, 418-422 (1 April 2005) | doi:10.1038/nm1211;
Apolipoprotein M is required for pre|[beta]|-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis
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Abstract
High-density lipoproteins (HDLs) are considered antiatherogenic because they mediate reverse cholesterol transport from the periphery to the liver for excretion and degradation. Here we show that mice deficient in apolipoprotein M (apoM), a component of the HDL particle, accumulated cholesterol in large HDL particles (HDL1) while the conversion of HDL to preβ-HDL was impaired.
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