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News and Views
Nature Medicine 11, 381 - 382 (2005)
doi:10.1038/nm0405-381
Nipping cat allergy with fusion proteins
Janet Kalesnikoff1 & Stephen J Galli1
- The authors are in the Department of Pathology at Stanford University School of Medicine, Stanford, California 94305-5324, USA. e-mail: sgalli@stanford.edu
Abstract
Immunotherapy for allergies can be an imperfect and unpredictable exercise; immunization with allergens can even lead to an acute allergic response. A new approach, involving fusing the allergen to a protein that modulates the immune response, could provide a more effective and safer alternative (pages 446–449).
When a person with a severe allergy to cats enters a friend's home for the first time, he or she does not have to be told whether there is a cat in residence. The runny eyes, itchy nose, tightening chest and other symptoms begin within minutes—shortly before the rush for the door.
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