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Nature Medicine 11, 376 - 377 (2005)
doi:10.1038/nm0405-376

MET orchestrates cancer and blood coagulation

Olga I Stenina1 & Edward F Plow1

  1. The authors are in the Department of Molecular Cardiology, the Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. e-mail: plowe@ccf.org


A new mouse model begins to unravel a longstanding mystery: why are cancers often associated with blood coagulation disorders?


The close interconnection between cancer and thrombosis, often referred to as Trousseau syndrome, was first appreciated almost one and a half centuries ago1, and has been widely documented in the basic and clinical literature. Indeed, markers of a perturbed coagulation system are often used as diagnostic and prognostic indicators of malignancy.

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